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Maria Ruiz Ortega on T-cell repertoires

  • (Virtual event) Chicago, IL United States (map)

Maria Ruiz Ortega, PhD

Icahn School of Medicine at Mount Sinai.

The CEIRR CMC holds bi-monthly research seminars that feature leading researchers who develop state-of-the-art computational methods to better understand respiratory viruses. These events are designed to facilitate in-depth discussions and provide ample opportunity for questions from the audience, with each seminar lasting 1 hour and 30 minutes.

Title:

Learning predictive signatures of HLA type from T-cell repertoires

Abstract:

The deep sequencing of immune repertoires from blood samples promises to offer diagnostic and precision medicine tools, and to help with the analysis of treatments and vaccinations and the design of immunotherapies. This study shows how, by training models on large datasets of annotated and unannotated repertoire sequencing, the human leukocyte antigen (HLA) type of patients can be computationally determined from their T-cell repertoire. This tool could be useful for typing repertoires for which the HLA is unknown, and to gain insight into the HLA restriction of T-cell receptor epitope specificity. It also provides lists of T-cell receptors that are associated to each HLA allele.

After you register, click on the Eventbrite event page for a zoom link.

Note: CEIRR CMC events are open only to CEIRR participants. The meeting and discussion are confidential.

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CEIRR Network Meeting 2025 Tool Showcase

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September 24

John Barton on predicting viral dynamics from genomic data