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Amanda Perofsky, PhD
Research Scientist in the Brotman Baty Institute at the University of Washington School of Medicine
Influenza viruses continually evolve new antigenic variants, through mutations in epitopes of their major surface proteins, hemagglutinin (HA) and neuraminidase (NA). Antigenic drift enables the reinfection of previously exposed individuals, but the contribution of this process to the dynamics of annual epidemics is not well understood. Here we link influenza A/H3N2 virus evolution to regional epidemic dynamics in the United States during 1997—2019. Read more.